Pharmacodynamics sustanon increases the permeability of the membranes of the cells of helminths for calcium ions, which causes generalized muscle contraction parasites and helminths inhibits glucose uptake by cells, thus reducing glycogen levels and stimulates the release of lactic acid compounds. The result is death of the parasite. sustanon is specifically active against cestodes and trematodes. Pharmacokinetics Absorption.Following oral administration sustanon is rapidly and completely absorbed. Maximum plasma concentration is achieved within 1-2 hours. The half-life of the drug in an unmodified form 1-2.5 hours with metabolites -. 4 hours to achieve a therapeutic effect needed for 4-6 (up to 10) hours to maintain the concentration of drug in the plasma equal to 0.19 mg / l. Distribution. It penetrates through the blood-brain barrier; CSF concentration is 10-20% of the plasma concentration.Penetrates into breast milk at a concentration of 20-25% of the serum concentration. Metabolism. Undergoes metabolism “first pass” through the liver. The main metabolites – hydroxylated products sustanon degradation. Withdrawal. Is carried out mainly through the kidneys. More than 80% of the dose excreted within 4 days, 90% of this amount -. 24 hours Renal failure. Since the drug predominantly renal route of excretion, when renal failure may be slowing down its elimination.Hepatic failure. In decompensated liver failure reduced drug metabolism in the liver, which is accompanied by elongation and increased half-life in the blood concentration of sustanon.
- Treatment of infections caused by different types of schistosomes (S. haematobium, S. mansoni, S.intercalatum, S.japonicum, S.mekongi)
- Treatment of infections caused by liver fluke (Clonorchis sinensis, Opistorchis viverrini) and lung fluke (Paragonimus westermani, et al. Types)
- Hypersensitivity to any component of the drug;
- Cysticercosis of eye;
- Interactions with rifampicin.
- Children under 4 years of age (safety and efficacy not established)
Be wary – decompensated liver failure, gepatolienalny schistosomiasis, cardiac arrhythmia.
Application of pregnancy and lactation
biltricid not recommended in the first 3 months of pregnancy. During the short course of therapy biltricid breast-feeding should be suspended for the whole period and the subsequent 24 hours.
Dosage and administration:
The tablet should be taken orally as a whole, without chewing, with a small amount of liquid before or during a meal. If the recommended single dose of the drug per day, the tablet should be taken in the evening. Repeated use of the drug during the day is recommended interval between doses of at least 4 and not more than 6 hours. Adults and children older than 4 years doses biltricid chosen strictly individual and depend on the type of pathogen. By Schistosoma haematobium: 40 mg / kg of body weight once. Duration of treatment 1 day. Schistosoma mansoni and Schistosoma intercalatum: 40 mg / kg 1 time a day or 20 mg / kg two times a day. Duration of treatment 1 day. Schistosoma japonicum, Schistosoma mekongi: 60 mg / kg 1 time a day or 30 mg / kg two times a day. Duration of treatment 1 day.Clonorchis sinensis, Opistorchis viverrini: 25 mg / kg, 3 times a day for 1-3 days. Paragonimus westermani, and other species: 25 mg / kg, 3 times a day for 2-3 days. For children up to 4 years. Safety of the drug in children younger than 4 years have not been established.
with the incidence of> 10% Digestive system: abdominal pain, nausea, vomiting. Central nervous system: headache, dizziness. With the incidence of> 1% and <10% Digestive system: lack of appetite.Central nervous system: dizziness, drowsiness. body as a whole: asthenia, fever. Musculoskeletal: myalgia. Skin: . urticaria With incidence of <0.01% body as a whole: allergic reactions (including generalized) including polyserositis. Digestive system: diarrhea mixed with blood. Cardiovascular system: arrhythmia. Central nervous system: convulsions. Adverse reactions can be caused both by sustanon (I, a direct relationship), as result of the endogenous response to the death of the parasite (II, an indirect relationship), and also be symptoms of infection (III, no relation). It is very difficult to make a differential diagnosis between I, II and III of the options and establish the exact cause of adverse reactions.
The interaction with other drugs
While the use of drugs that induce enzyme system of liver cytochrome P450, such as anticonvulsants, dexamethasone concentration sustanon in plasma can be reduced, and in combination with drugs that inhibit these enzymes, such as cimetidine – rise. Chloroquine decreases sustanon concentration in blood plasma.
When decompensated liver disease and schistosomiasis gepatolienalny biltricid should be used with caution because of the risk of its longer presence in elevated concentrations in the bloodstream, including collateral vessels. Such patients for treatment may be hospitalized. In cases of cardiac arrhythmias, and while receiving treatment with drugs digitalis biltricid should be carried out under medical supervision.
Patients who live or lived in endemic for cysticercosis and trematodozov areas recommended for treatment in a hospital.
Effects on ability to drive / moving mechanisms
When applying biltricid should refrain from driving / moving mechanisms in the day / day of the drug, and over the next 24 hours.
On 6 tablets in a bottle amber glass, equipped with a plastic stopper; 1 bottle with instruction on use in a cardboard box